Trichlorotert butanol, as an alcohol antibacterial agent, has the ability to coagulate bacterial proteins and globulin. The initial dosage form used for ophthalmic or injectable administration is generally at a concentration of 0.5% (W/V). It is commonly used as an antibacterial agent in adrenaline solutions, posterior pituitary extract, and ophthalmic preparations for the treatment of pupil constriction.
Haohan Chromatography (Shandong) Application Technology Development Co., Ltd. has established a gas chromatography analysis method for the determination of related substances in trichlorotert butanol and revised the quality standards for this excipient Method: A capillary column with polyethylene glycol (PEG-20M) as the stationary phase The detectors are FID (acetone) and ECD (chloroform), respectively; Acetone and trichloromethane showed a good linear relationship between peak area and concentration in the ranges of 0.5-45 μ g · mL ^ (-1) and 5-510 ng · mL ^ (-1), respectively (r values of 0.9997 and 0.9995, respectively); The average recovery rates of acetone and trichloromethane were 95.9% And 107.9%, both meet the requirements of methodological research; The establishment method can be added to the quality standards of the Chinese Pharmacopoeia for the quality control of trichlorotert butanol
Name: Capillary Column
Specification: 30m * 0.32mm * 0.25um
model; PEG-20M
Application: Determination of Acetone and Trilv Methane in Trichlorotert butanol Medicinal Excipients
Applicable to:
Agilent 490 online/portable, 48905890689088608890
Shimadzu GC-14C, GC-2010，GC-2014，GC-2030
Thermo Fisher Scientific 1310130016101600
Varian 3800 Series
Brooke PE580590680690
Panno A90, Fuli GC9790, Huaai, Tianrui, Tianmei, GC7900， Chuanyi, Beifen Ruili, Dongxi Electronics, Lunan Ruihong, Jiedao/Kexiao
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三氯叔丁醇作為一種醇類(lèi)抑菌劑，具有凝固細(xì)菌蛋白和球蛋白的作用。最初用于眼用制劑或注射給藥的劑型中，其一般使用濃度為0.5%(W/V)?，F(xiàn)常作為抑菌劑用于腎上腺素溶液、垂體后葉提取液和治療縮瞳的眼用制劑中。
浩瀚色譜（山東）應(yīng)用技術(shù)開(kāi)發(fā)有限公司，建立三氯叔丁醇有關(guān)物質(zhì)測(cè)定的氣相色譜分析法,對(duì)該輔料質(zhì)量標(biāo)準(zhǔn)進(jìn)行修訂.方法:以聚乙二醇(PEG-20M)為固定液的毛細(xì)管柱.檢測(cè)器分別為FID(丙酮)和ECD(三氯甲烷);丙酮和三氯甲烷分別在0.5~45μg·mL^(-1)和5~510 ng·mL^(-1)范圍內(nèi)峰面積與濃度呈良好的線性關(guān)系(r值分別為0.9997和0.9995);丙酮和三氯甲烷平均回收率分別為95.9%.和107.9%,均符合方法學(xué)研究要求;建立方法可增訂入中國(guó)藥典質(zhì)量標(biāo)準(zhǔn),用于三氯叔丁醇質(zhì)量控制.
名稱：毛細(xì)管柱
規(guī)格：30m*0.32mm*0.25um
型號(hào);PEG-20M
應(yīng)用：三氯叔丁醇藥用輔料中丙酮及三lv甲烷的測(cè)定
適用于：
安捷倫490在線/便攜，4890,5890,6890,7820,7890,8860,8890
島津GC-14C，GC-2010，GC-2014，GC-2030
賽默飛1310,1300,1610,1600
瓦里安3800系列
布魯克PE580,590,680,690
磐諾A90，福立GC9790，華愛(ài)，天瑞，天美，GC7900，川儀，北分瑞利，東西電子，魯南瑞虹，捷島/科曉
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